THE IMPORTANCE OF ACID DOCOSAHEXAENOIC (DHA) IN PREGNANCY AND CHILD DEVELOPMENT

Autores

  • Marcilene Camilo Heidmann Soccol Unifacvest
  • Lais Cristina Rodrigues Unifacvest
  • Alexandre Antunes Ribeiro Filho Unifacvest

Palavras-chave:

Pregnancy, Lactation, Childhood, Omega-3 fatty acids, DHA

Resumo

Os ácidos graxos poliinsaturados, especialmente o ácido docosahexaenóico (DHA), são essenciais não só para o desenvolvimento neurológico quanto para a função visual da criança. A maior necessidade e DHA ocorre durante o desenvolvimento intrauterino e nos primeiros dois anos de vida. A mãe é um fator determinante na oferta desses ácidos graxos para a criança, pois a mesma não tem capacidade de elongação e dessaturação dos ácidos graxos. O objetivo deste trabalho foi apresentar uma revisão da literatura a partir da seleção de artigos publicados em revistas científicas indexadas em bases de dados como PubMed, Scientific Electronic Library Online (SciELO) e Google Acadêmico, focada em publicações relacionadas os temas ácidos graxos ômega-3, DHA, gestação e lactação, publicados nos últimos anos. Os estudos indicam que, independentemente da dieta, toda gestante deve receber suplemento diário de DHA, preferencialmente obtido industrialmente através de algas, evitando-se o risco de contaminação por metais pesados. Na ausência de leite materno, pode produzir carência deste nutriente por parte do recém-nascido como também transtornos, principalmente no desenvolvimento visual e cognitivo.

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Referências

Valenzuela AB, Nieto SK. Ácidos grasos omega-6 y omega-3 en la nutrición perinatal: su importância em el desarrolo del sistema nervioso y visual. Revista Chilena de Pediatría. 2003; 74:149-157.

Aranceta J, Pérez-Rodrigo C. Recommended dietary reference in takes, nutritional goals and dietary guidelines for fat and fatty acids: a systematic review. Britsh Journal of Nutrition. 2012; 107:S8-S22.

Janssen CIF, Kiliaan AJ. Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: The influence of LCPUFA on neural development, aging, and neurodegeneration. Progress in Lipid Research. 2014; 53(1):1–17. Disponível em: http://dx.doi. org/10.1016/j.plipres.2013.10.002.

Koletzko B, Poindexter B, Uauy R. Nutritional care of preterm infants: Scientific Basis and Practical Guidelines. World Review of Nutrition and Dietetics. vol. 110. 2014.

Koletzko B. Human milk lipids. Annals of Nutrition and Metabolism. 2016; 69(suppl 2):S28-40.

Wadhwani N, Patil V, Joshi S. Maternal long chain polyunsaturated fatty acid status and pregnancy complications. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 2018; 136:143-152.

Carlson SJ, Colombo J, Gajewski BJ, Gustafson KM, Mundy D, Yeast J, et al. The role of the w-3 fatty acid DHA in the human life cycle. Journal of Parenteral and Enteral Nutrition. 2013; 37(1):15–22.

Nordgren TM, Lyden AE, Anderson-Berry A, Hanson C. Omega-3 fatty acid intake of pregnant women and women of childbearing age in the united states: Potential for deficiency? Nutrients. 2017; 9(3):1-12.

Kovács A, et al. Fatty acids in early human milk after preterm and full-term delivery. Journal of Pediatric Gastroenterology and Nutrition. 2005; 41(4):454–459.

Kus MMM, Mancini-Filho J. Ácidos Graxos: Eicosapentaenoico (EPA) e Docosahexaenoico (DHA). Série de Publicações Ilsi Brasil - Funções Plenamente Reconhecidas de Nutrientes. 2010; 17:1-20.

Koletzko B, Lien E, Agostoni C, Bohles H, Campoy C, Cetin I, et al. The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. Journal of Perinatal Medicine. 2008; 36(1):5-14.

Gunarte AW, Makrides M, Coliins CT. Maternal prenatal and/or pos-natal n-3 ling chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood. The Cochrane Database on Systematic Reviews. 2015; 7:CD010085.

Innis SM. Impact of maternal diet on human milk composition and neurological development of infants. The American Journal of Clinical Nutrition. 2014; 99(3):734s-741s.

Kar S, Wong M, Rogozinska E, Thangaratinam S. Effects of omega-3 fatty acids in prevention of early preterm delivery: a systematic review and meta-analysis of randomized studies. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2016; 198:40-46.

Best KP, Gold M, Kennedy D, Martin J, Makrides M. Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials. The American Journal of Clinical Nutrition. 2016; 103(1):128-143.

Merey LSF, Palhares DB, Porto KRA, Muller KTC. Ácidos graxos polinsaturados no sangue de gestantes suplementadas com ômega-3 e óleo de linhaça dourada. Interações. 2018; 19(4): 845-853.

Moura AR, Azevedo FHC. Evidências científicas sobre a alimentação de gestantes. Revista Saúde em Foco. 2018; 5(1):78-90.

Campos ABF, Pereira, RA, Queiroz, Saunders C. Ingestão de energia e de nutrientes e baixo peso ao nascer: estudo de coorte com gestantes adolescentes. Revista de Nutrição. 2013; 26(5):551-561.

Kuratko CN, Barrett EC, Nelson EB, Salem N, Jr. The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. Nutrients. 2013; 5(7):777-810.

Bourlieua C, Michalski MC. Structure–function relationship of the milk fat globule. Current Opinion in Clinical Nutrition & Metabolic Care. 2015; 18:118-127.

Calder PC. Docosahexaenoic acid. Annals of Nutrition and Metabolism. 2016; 69(1):8-21.

Innis SM, Elias SL. Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. The American Journal of Clinical Nutrition. 2003; 77:473-478.

Brown TT, Jernigan TL. Brain development during the preschool years. Neuropsychology Review. 2012; 22(4):313-333.

Almeida CB, Moretti MYRS, Oliveira FLCOS. Lipídios e o desenvolvimento cerebral. 2019; 10:20-29. Disponível em: http://mhnpjournal.biomed- 28 Nutrição e Desenvolvimento Cerebral no Lactente / ILSI Brasil central.com/articles/10.1186/s40748-017-0061-1.

Carlson SE, Colombo J. Docosahexaenoic acid and arachidonic acid nutrition in early development. Advances in Pediatrics. 2016; 63(1): 453-471.

Gonzáles MI. Ácidos grasos ômega 3: benefícios y fuentes. Interciencia. 2002; 27:128-136.

Heaton AE, Meldrum SJ, Foster KJ, Susan L. Prescott SL, Simmer K. Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy? Frontiers in Human Neuroscience. 2013; 7(774):1-12.

Sherry CL, Oliver JS, Marriage BJ. Docosahexaenoic acid supplementation in lactating women increases breast milk and plasma docosahexaenoic acid concentrations and alters infant omega 6:3 fatty acid. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 2015; 95:63-69.

Torres AG, Trugo NM. Evidence of inadequate docosahexaenoic acid status in Brazilian pregnant and lactating women. Revista de Saúde Pública. 2009; 43(2):359-368.

Nishimura RY, Castro GS, Jordao AA Jr., Sartorelli DS. Breast milk fatty acid composition of women living far from the coastal area in Brazil. Jornal de Pediatria. 2013; 89(3):263-268.

Innis SM. Omega-3 Fatty acids and neural development to 2 years of age: do we know enough for dietary recommendations? Journal of Pediatric Gastroenterology and Nutrition. 2009; 48(Suppl 1):S16-24.

Lassek WD, Gaulin SJ. Maternal milk DHA content predicts cognitive performance in a sample of 28 nations. Maternal & Child Nutrition. 2015; 11(4):773-779.

Vasconcelos LG, Gomes CB, Malta MB, Dichi I, Benício MHD, Carvalhaes MABL. Ingestão insuficiente de ácido graxo alfa-linolênico (18: 3n-3) durante a gestação e os fatores associados. Revista de Nutrição. 2017; 30(4)443-453.

Fernandes AC, Medeiros CO, Bernardo GL, Ebone MV, Di Pietro PF, Assis MAA, et al. Benefits and risks of fish consumption for the human health. Revista de Nutrição. 2012; 25:283-295.

Noakes PS, Vlachava M, Kremmyda LS, Diaper ND, Miles EA, Erlewyn-Lajeunesse M, et al. Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo. The American Journal of Clinical Nutrition. 2012; 95(2):395-404.

Garcia-Rodriguez CE, Olza J, Aguilera CM, Mesa MD, Miles EA, Noakes PS, et al. Plasma inflammatory and vascular homeostasis biomarkers increase during human pregnancy but are not affected by oily fish intake. The Journal of Nutrition. 2012; 142(7):1191-1196.

Bonham MP, Duffy EM, Wallace JM, Robson PJ, Myers GJ, Davidson PW, et al. Habitual fish consumption does not prevent a decrease in LCPUFA status in pregnant women (The Seychelles Child Development Nutrition Study). Prostaglandins, Leukotrienes, and Essential Fatty Acids. 2008; 78(6):343-350.

Rogers LK, Valentine CJ, Keim SA. DHA supplementation: current implications in pregnancy and childhood. Pharmacological Research: The Official Journal of the Italian Pharmacological Society. 2013; 70(1):13-19.

Fereidooni B, Jenabi E. The use of ômega 3 on pregnancy outcomes: a single-center study. Journal of Pakistan Medical Association. 2014; 64 (12): 1363-1365.

Akerele AO, Cheema SK. A balance of ômega-3 and ômega-6 polyunsaturated fatty acids is importante in pregnancy. Journal of nutrition & Intermediary Metabolism. 2016; 5:23-33.

Meher A, Randhir K, Mehendale S , Wagh G, Joshi S. Maternal fatty acids and their association with birth outcome: a prospective study. PloS One. 2016; 27:11(1)e0147359.

Carvalho SMB, Santos JBN, Quadros IAAO, Junqueira ML, et al. Suplementação de ômega-3 no período gestacional: aspectos relevantes. International Journal of Nutrology. 2018; 11(S01):S324-S327.

Elias SL, Innis SM. Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. The American Journal of Clinical Nutrition. 2001; 73:807-814.

Stender S, Dyerberg J. Influence of trans fatty acids on health. Annals of Nutrition and Metabolism. 2004; 48: 61-68.

Smith SL, Rouse CA. Docosahexaenoic acid and the preterm infant. Maternal Health, Neonatology and Perinatology. 2017; 3:22. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/29238605.

Lapillonne A, Jensen CL. Reevaluation of the DHA requirement for the premature infant. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 2009; 81:143-50. Disponível em: http://dx.doi.org/10.1016/j.plefa.2009.05.014.

Sanders TAB. DHA status of vegetarians. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 2009; 81:137-41. Disponível em: http://dx.doi.org/10.1016/j.plefa.2009.05.013.

Bortolozo EAFQ, Sauer E, Santos MS, Baggio RS, Junior GS, Farago PV, et al. Supplementation with the omega-3 docosahexaenoic acid: influence on the lipid composition and fatty acid profile of human milk. Revista de Nutrição. 2013; 26(1):27-36.

Magalhães DMO. Avaliação da ingestão de ácidos gordos polinsaturados ômega 3 numa amostra de grávidas. Dissertação (Mestrado em Nutrição Clínica) – Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto. Porto, 2017; 45p.

Imhoff-Kunsch B, Stein AD, Martorell R, Parra-Cabrera S, Romieu I, Ramakrishnan U. Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. Pediatrics. 2011; 128(3):e505-512.

Escamilla-Nuñez MC, Barraza-Villarreal A, Hernández-Cadena L, Navarro-Olivos E, Sly PD, Romieu I. Omega-3 fatty acid supplementation during pregnancy and respiratory symptoms in children. Chest. 2014; 146 (2):373-382.

Gustafson KM, Carlson SE, Colombo J, Yeh HW, Shaddy DJ, Li S, et al. Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 2013; 88(5):331-338.

Li GL, Chen HL, Zhang WX, Tong Q, Yan YE. Effects of maternal ômega-3 fatty acids supplementation during pregnancy/lactation on body composition os the offspring: A systematic review and meta-analysis. Clinical Nutrition. 2018; 37(5): 1462-1473.

Silva SMCS, Mura JP. Tratado de alimentação, Nutrição e Dietoterapia, 2° edição. Roca, 2011. Disponível em: http://dowloadacademico.blogspot.com.br/2013/12/tratado-de-alimentacaonutricao-e.html.

Donahue SM, Rifas-Shiman SL, Gold DR, Jouni ZE, Gillman MW, Oken E. Prenatal fatty acid status and child adiposity at age 3 y: results from a US pregnancy cohort [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. The American Journal of Clinical Nutrition. 2011; 93(4):780-788.

Warstedt K, Fuhuhjelm C, Fälth-Magnusson K , Fagerås M, Duchén K. High levels of omega 3 fatty acids in milk from ômega-3 fatty acid-supplemented mothers are related to less immuniglobulin E-associated disease in infancy. Acta Pediatrica. 2016; 105(11):1337-1347.

Gould JF, Anderson AJ, Yelland LN, Gibson RA, Makrides M. Maternal characteristics influence response to DHA during pregnancy. Prostaglandins, leukotrienes, and Essential Fatty Acids. 2016; 108:5-12.

Boucher O, Burden MJ, Muckle G, Saint-Amour D, Ayotte P, Dewailly E, et al. Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age. The American journal of Clinical Nutrition. 2011; 93(5):1025-1037.

Richardson AJ, Burton JR, Sewell RP, Spreckelsen TF, Montgomery P. Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB study). PloS One. 2012; 7(9):e43909.

Dalton A, Wolmarans P, Witthuhn RC, Van Stuijvenberg ME, Swanevelder SA, Smuts CM. et al. A randomised control trial in schoolchildren showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source. Prostaglandins, leukotrienes, and Essential Fatty Acids. 2009; 80(2-3):143-149.

Kennedy DO, Jackson PA, Elliott JM, Scholey AB, Robertson BC, Greer J, et al. Cognitive and mood effects of 8 weeks' supplementation with 400 mg or 1000 mg of the omega-3 essential fatty acid docosahexaenoic acid (DHA) in healthy children aged 10-12 years. Nutritional Neuroscience. 2009; 12(2):48-56.

McNamara RK, Able J, Jandacek R, Rider T, Tso P, Eliassen JC, et al. Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study. The American Journal of Clinical Nutrition. 2010; 91(4):1060-1067.

Kohlboeck G, Glaser C, Tiesler C, Demmelmair H, Standl M, Romanos M, et al. Effect of fatty acid status in cord blood serum on children's behavioral difficulties at 10 y of age: results from the LISAplus Study. The American Journal of Clinical Nutrition. 2011; 94(6):1592-1599.

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Publicado

24-01-2022

Como Citar

CAMILO HEIDMANN SOCCOL, Marcilene; RODRIGUES, Lais Cristina; ANTUNES RIBEIRO FILHO, Alexandre. THE IMPORTANCE OF ACID DOCOSAHEXAENOIC (DHA) IN PREGNANCY AND CHILD DEVELOPMENT. Scientia Generalis, [S. l.], v. 3, n. 1, p. 22–32, 2022. Disponível em: http://scientiageneralis.com.br/index.php/SG/article/view/379. Acesso em: 18 abr. 2024.

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